The answer to your question really depends on what you need your machine to do. I dual-boot WinXP (for FL Studio) and Linux Fedora 6 (for everything else).
I'd heard of Fedora before but what the capabilities to Fedora? I had used Ubuntu before but I doubt you can use FL on that OS even though that would a good idea.
Much of a muchness really, they're both Linux-based so unless WINE has matured considerably further than previously then FL won't work in it. Not to mention all the VST plugins. I use Fedora since I started using Linux at Red Hat 4.0 and just got used to the way RH did things.
WINE is an API layer (Wine Is Not an Emulator) for allowing WIN32 binaries to run in Linux. Many applications work, but many do not. Their website is http://www.winehq.com/.
I've been using Acid Pro 6 and Pro Tools 7.3 with each VST on Vista without problems yet. From the sound of things I got a feeling the problems are coming though.
Simple, but hugely powerful. Compact, an OS that could fit on a single floppy disk! Hugely expandable, there was no (software) system or resource that could not be patched or entirely changed... even those residing in the ROM! Elegant, everything (directory structure, filenames) were in plain english. Customisable... Make it work how you want not the other way round.
Its a shame how Commodore went and funked it up! If Commodore hadn't of screwed things up and the AmigaOS was running on modern hardware it would be kicking the arse of any PC/Mac/Linux box... easily!
There is an (ongoing) effort to re-write a clone of the AmigaOS for modern PC hardware but unfortunately its nothing more than a hobbyist effort (though I'm sure those doing it would probably disagree!). Sadly though, its something of a wet dream for me... a powerful OS with a minimal footprint that allows the hardware to do its job instead of swamping it with completely unnessecary crap like Windows does! That would be heaven... and you would really see what modern hardware is really capable of!
The only thing that comes close to it (in terms of power and customisation) is Linux but I think most (if not all) varients are too much for the average person to get their head around!